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A method and apparatus for synthesizing vesicles by interdiffusion of stationary phases


This invention relates to the method for  synthesizing unilamellar vesicles comprising contacting a first stationary, lipid dissolved, water miscible, organic phase, with a second stationary aqueous phase, characterized in that the mixing of the two phases is driven by the inter-diffusion of one phase into the other, resulting in a self assembly of lipids into vesicles. The  vesicle forming materials are selected from a combination of phospholipid molecules, cholesterol, or other vesicle forming amphiphilic molecules.

Liposomal applications to the Pharmaceutical industry as a drug delivery system, as model for artificial cells, in nano cosmetology, gene delivery and in food industry for oral nutritional supplements has been well documented (Lasic, 1993). In particular it is a potential system for cancer chemotherapy, fungal infections, tropical parasites and some other bacterial infections. Other application include but are not limited to water based paints and coatings, to clean radioactive and toxic metals form solution by using anchored membrane chelator which forms complex and precipitate out; to enhance degradation of carbohydrates in oil spills by using bacterial encapsulated liposomes etc.
The current invention provides a generic scalable technique to produce liposomal suspensions. The technique may be adapted to in-situ synthesis of liposomes for drug or gene delivery applications, or to other laboratory apparatus or industrial equipment used for making liposomes for other applications.

Indian patent application no. 2324/MUM/2011
Inventors: P Sunthar, Sopan Mahadeo Phapal