Bacterial diseases are among the leading causes of human deaths and the
most important health hazards in the developing parts of the world. The development
of resistance to the existing drugs is also making the treatment ineffective.
Thus, it is necessary to develop new antibacterial drugs with novel mechanism
of action. Recent studies have shown that FtsZ plays an essential role in
bacterial cell division.
FtsZ is a protein encoded by the FtsZ gene that assembles into a ring at
the future site of the septum of bacterial cell division. FtsZ, named after "Filamenting
temperature-sensitive mutant Z", is a prokaryotic homologue to the eukaryotic
cytoskeleton protein tubulin. FtsZ is highly conserved in bacteria and the
perturbation of FtsZ functions has been shown to induce deleterious effects
in bacteria. Thus, there is a need to develop new antibacterial drugs with
novel mechanism of action. present inventors provides a pharmaceutical composition
acid or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable
excipients for therapeutic or prophylactic treatment of bacterial infections
and diseases associated therewith.
The present invention relates to a potential antibacterial agent using
the assembly of
FtsZ (filamenting temperature-sensitive mutant Z) monomers as the target
screening of a group of compounds of diverse chemical structures. The effects
compounds were examined on the assembly of FtsZ monomers.
1. Healthcare industry.
Indian patent application no. 2345/DEL/2008 Patent grant no.
Inventors: A Surolia, Beuria Tushar Kant, and Dulal Panda