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Pharmaceutical composition for therapeutic or prophylactic treatment of bacterial infections and associated diseases
 

Bacterial diseases are among the leading causes of human deaths and the most important health hazards in the developing parts of the world. The development of resistance to the existing drugs is also making the treatment ineffective. Thus, it is necessary to develop new antibacterial drugs with novel mechanism of action. Recent studies have shown that FtsZ plays an essential role in bacterial cell division.
FtsZ is a protein encoded by the FtsZ gene that assembles into a ring at the future site of the septum of bacterial cell division. FtsZ, named after "Filamenting temperature-sensitive mutant Z", is a prokaryotic homologue to the eukaryotic cytoskeleton protein tubulin. FtsZ is highly conserved in bacteria and the perturbation of FtsZ functions has been shown to induce deleterious effects in bacteria. Thus, there is a need to develop new antibacterial drugs with novel mechanism of action. present inventors provides a pharmaceutical composition comprising 3-{5-[4-Oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-furan-2-yl}-benzoic acid or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients for therapeutic or prophylactic treatment of bacterial infections and diseases associated therewith.

The present invention relates to a potential antibacterial agent using the assembly of FtsZ (filamenting temperature-sensitive mutant Z) monomers as the target for screening of a group of compounds of diverse chemical structures. The effects of 81 compounds were examined on the assembly of FtsZ monomers.

Industrial application:
1. Healthcare industry.

Indian patent application no. 2345/DEL/2008 Patent grant no.
Inventors: A Surolia, Beuria Tushar Kant, and Dulal Panda