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Layer by Layer self assembled magnetic PLGA-CHITOSAN nanoparticles for dual drug delivery and hyperthermia applications)


This invention relates generally to nanocomposites, and more specifically to multi-layer nanocomposites comprising hydrophilic and hydrophobic layers. Multifuncional nanosystems are typically used for the treatment of various diseases such as cancer, hypothermia and the like.  A system that can provide chemical and radiation therapy together is an example of a multifunctional system.  Nanocomposites are widely used as multifunctional systems due to the ease of preparation and stability in biological fields and during storage. These include multiple layers of hydrophobic polymers and hydrophilic polymers.  They are generally held together using a surfactant material.  Further, the layers may be loaded with separate drugs thus making the nanocomposite a very effective multifunctional system. Nanocomposites may also magnetic nanoparticles loaded in to the hydrophobic layer. However, current techniques used for synthesis of nanocomposites generally lack the ability to encapsulate both hydrophilic and hydrophobic drug in the same nanocomposite.  Therefore, there is a need for a multifunctional system that delivers both a hydrophobic and a hydrophilic drug effectively.

In present invention, a nanocomposite is provided.  The nanocomposite includes a negatively charged polymer layer  comprising a first drug and a positively charged polymer layer encapsulating the negatively charged polymer layer and comprising a second drug.  The negatively charged polymer layer and the positively charged polymer layer are held together by electrostatic forces.

Indian patent application no. 811/MUM/2011

Inventors: Rohit Srivastava, Dhirendara Bahadur, Asiskhan S Mohammed Aslam, Sonara Dhirenkumar Keshavlal