INDUSTRIAL RESEARCH & CONSULTANCY CENTRE OFFICE OF THE DEAN(R&D) INDIAN INSTITUTE OF TECHNOLOGY,BOMBAY.
Circular No. 21/2017
RECRUITMENT FOR PROJECT
Applications are invited from the citizens of India for filling up the following temporary
for the sponsored project
Biosciences and Bioengineering
of this Institute. The
temporary initially for a period of
and tenable only for the duration of the project. The requisite qualification & experience etc. are given below:
Project Code, Project Title & Funding Agency
16DBT006 :"Interplay Of Spatio-Temporal Synaptic Drive And Spike Propagation In Shaping Electrical Activity Of Urinary Bladder Smooth Muscle: A Computational Investigation"
About the project: As populations age, urinary bladder overactivity is emerging as an increasingly common debilitating condition confronting the elderly. Voiding of the bladder depends on coordinated contraction of the smooth muscle (detrusor smooth muscle, DSM) present in its wall, which in turn depends closely on the electrical activity in the muscle cells. A clear understanding of bladder physiology and pathophysiology rests therefore on a correspondingly clear understanding of the properties of electrical signals generated in DSM. However, these signals are poorly comprehended since the smooth muscle cells are electrically interconnected by low resistance pathways (gap junctions), forming a 3- dimensional syncytium, which renders problematic the interpretation and analysis of signals occurring in them. As an example, while spikes (action potentials) in electrically isolated cells such as skeletal muscle cells generally display a stereotypical waveform, in DSM a variety of spike shapes can be recorded even in a single smooth muscle cell.
As in other organs, analysis of spikes can offer many insights into the electrical functioning of the organ. In detrusor smooth muscle, such analysis is hampered by incomplete knowledge of how the spikes are generated, how they propagate, and how they interact with synaptic potentials in the syncytium. Using computational approaches closely allied to experimental data, our aim in this project is twofold. The first is to simulate the spike recorded in detrusor smooth muscle cells, using the Hodgkin-Huxley and Goldman equation formalisms, together with the associated Ca dynamics, to model the underlying ion channels. The second is to simulate, using compartmental modelling techniques, spatio-temporally distributed neurotransmission in a model syncytium that represents faithfully the DSM and its innervation. Subsequently, these components are to be brought together in a comprehensive model which we believe will aid us in better understanding the native electrical characteristics of the detrusor. They will also be of heuristic value in predicting how alterations in these characteristics may give rise to pathophysiological conditions that are marked by disordered electrical activity.
Position & Salary
Research Associate (1 Post
) Consolidated salary Rs.36000/- p.m. + HRA
Ph.D/MD/MS/MDS or equivalent degree or having 3 years of research, teaching and design and developement experience after MVSc/M.Pharm/ME/M.Tech with at least one research paper in Science Citation Indexed (SCI) journal
Will be required to work on large-scale integrative simulations, which will bring together the constituent elements. These elements are, for instance; (i) the active ion channels and the spike in individual cells namely smooth muscle cells and efferent neurons, (ii) various components of Ca dynamics, (iii) neurotransmission drive generated by parasympathetic efferent neuron, (iv) the bundled syncytium. Should have experience in modeling ion channels and Ca dynamics in autonomic neuron in the NEURON platform. A detailed understanding of the current research available about the electrophysiology of detrusor and parasympathetic neuron will also be required. These tasks will require an expertise in coding and troubleshooting issues that may arise during the stepwise realization of a comprehensive DSM model. A background of medical education in conjunction with work experience focused on patients with spinal cord injury or bladder disorders would be an added advantage.
The appointment is for time bound project and the candidate is required to work mainly for the successful completion of the
. The selection committee may offer lower or higher designation and lower or higher salary depending upon the experience and performance of the candidate in the interview.
Candidate possessing the requisite qualification and experience should apply online at
on or before
20th February, 2017
Call letters will be sent through e-mail to the candidates shortlisted for interview and will also be displayed on IRCC website. Candidates called for interview will be
required to attend at their own expenses.
Assistant Registrar (R&D)
1.All Heads/In-charges of the Departments/Schools/Centres/Sections.