INDUSTRIAL RESEARCH & CONSULTANCY CENTRE OFFICE OF THE DEAN(R&D) INDIAN INSTITUTE OF TECHNOLOGY,BOMBAY.
Circular No. 105/2017
RECRUITMENT FOR PROJECT
Applications are invited from the citizens of India for filling up the following temporary
for the sponsored project
Biosciences and Bioengineering
of this Institute. The
temporary initially for a period of
and tenable only for the duration of the project. The requisite qualification & experience etc. are given below:
Project Code, Project Title & Funding Agency
16DBT006 :"Interplay Of Spatio-Temporal Synaptic Drive And Spike Propagation In Shaping Electrical Activity Of Urinary Bladder Smooth Muscle: A Computational Investigation"
(DEPTT OF BIOTECHNOLOGY)
About the project: As populations age, urinary bladder overactivity is emerging as an increasingly common debilitating condition confronting the elderly. Voiding of the bladder depends on coordinated contraction of the smooth muscle (detrusor smooth muscle, DSM) present in its wall, which in turn depends closely on the electrical activity in the muscle cells. A clear understanding of bladder physiology and pathophysiology rests therefore on a correspondingly clear understanding of the properties of electrical signals generated in DSM. However, these signals are poorly comprehended since the smooth muscle cells are electrically interconnected by low resistance pathways (gap junctions), forming a 3- dimensional syncytium, which renders problematic the interpretation and analysis of signals occurring in them. As an example, while spikes (action potentials) in electrically isolated cells such as skeletal muscle cells generally display a stereotypical waveform, in DSM a variety of spike shapes can be recorded even in a single smooth muscle cell.
As in other organs, analysis of spikes can offer many insights into the electrical functioning of the organ. In detrusor smooth muscle, such analysis is hampered by incomplete knowledge of how the spikes are generated, how they propagate, and how they interact with synaptic potentials in the syncytium. Using computational approaches closely allied to experimental data, our aim in this project is twofold. The first is to simulate the spike recorded in detrusor smooth muscle cells, using the Hodgkin-Huxley and Goldman equation formalisms, together with the associated Ca dynamics, to model the underlying ion channels. The second is to simulate, using compartmental modelling techniques, spatio-temporally distributed neurotransmission in a model syncytium that represents faithfully the DSM and its innervation. Subsequently, these components are to be brought together in a comprehensive model which we believe will aid us in better understanding the native electrical characteristics of the detrusor. They will also be of heuristic value in predicting how alterations in these characteristics may give rise to pathophysiological conditions that are marked by disordered electrical activity.
Position & Salary
Research Associate (1 Post
) Consolidated salary Rs.36000/- p.m. + HRA
Ph.D/MD/MS/MDS or equivalent degree or having 3 years of research, teaching and design and developement experience after MVSc/M.Pharm/ME/M.Tech with at least one research paper in Science Citation Indexed (SCI) journal
Will be required to carry out simulations for a smooth muscle syncytium, particularly in relation to propagation of (i) Action Potentials, (ii) Ca signals in the syncytium. This arena encompasses several sub-domains, and will in itself pose challenges of integration. Chiefly, voltage spread in a bundled syncytium, for action potential propagation as well as following synaptic drive, is to be explored. Various features of action potential spread (e.g. retention/ loss of foot of action potential, extent and efficacy of spatial spread as a function of gap junction conductance and of intensity of spatio-temporal synaptic drive) are to be investigated. Another prime function will be to explore algorithmic mechanisms of incorporating Ca movements between cells in the syncytium, as driven by its concentration gradients. While Ca movement through the cytosol can be driven by diffusion equations, across a gap junction, which is modelled as a resistive link, other mechanisms will need to be conceived. The work will also involve enhancing the efficiency of simulations using the techniques currently available.
The appointment is for time bound project and the candidate is required to work mainly for the successful completion of the
. The selection committee may offer lower or higher designation and lower or higher salary depending upon the experience and performance of the candidate in the interview.
Candidate possessing the requisite qualification and experience should apply online at
on or before
12th June, 2017
Call letters will be sent through e-mail to the candidates shortlisted for interview and will also be displayed on IRCC website. Candidates called for interview will be
required to attend at their own expenses.
Asstt. Registrar (R&D)
1.All Heads/In-charges of the Departments/Schools/Centres/Sections.