Lab is specialized in chemical synthesis of complex glycans which are present on the surfaces of bacteria and viruses. These glycans can be conjugated with proteins for vaccine development.
For this approach, one needs to know the specific structures of the glycans. Small sugar based molecules can be synthesised, to be tested as virus entry inhibitors, if the details about the nature of host-virus interaction at molecular level are available
Look at standardizing and developing a chemical synthesis protocol for the anti-viral drug (Prof. Gudi ravigudi@iitb.ac.in, Prof. Mahajani sanjaym@che.iitb.ac.in, Prof. Wangikar wangikar@iitb.ac.in )
We can participate in the synthesis of anti-viral agents. Also we can provide structures of large number of compounds which can be subjected to virtual screening by computational methods to identify the lead compounds (I had a joint MSc project with Prof Prasenjit Bhowmik of BSBE) on similar approach.
We can also supply available compounds in good quantities if someone is interested in screening directly by experimental methods.
Design and large scale synthesis of anti viral agents
We are interested in synthesising anti-viral agents. New chemicals can be prepared by our methods and known anti-viral agents can be prepared in large scale. We can design and synthesize new anti-viral agents.
In collaboration with other research groups, we are interested in contributing generation and testing of various anti-viral agents which will be effective against COVID-19.
Our strength is to prepare new chemical entities in large numbers and quantities. We will be happy to write a proposal or can be part of a larger mission.
We can join with expertise in organic synthesis of compounds that can be tested. We have some compounds that worked well as anti-bacterials but not tested for antiviral. These can be tried for antiviral activity.
Have experience in all aspects of virology, from culture to cultivation to understanding their biology/evolution, detection of viruses, and therapy development.
In-situ Gel for Rapid Capture and Inactivation of 2019-nCoV