Has worked on technology to differentiate virus and bacteria. Rapid confirmative categorization of infections in clinical settings as bacterial or viral is frequently challenging due to the vague presentations of diseases and symptomatic similarities.
Many earlier studies have shown the bactericidal effect of silver nanoparticles which, in the current study has been enhanced by synergistic action of polycationic chitosan stabilizers.
An impedimetric electro-active polymer (polyaniline) modified paper substrate has been developed for generic differentiation of bacteria and virus based on their interaction with chitosan stabilized silver nanoparticles.
These characteristic electrical impedance signatures of bacteria and virus, established here, have promising prospects in inexpensive and scalable bedside diagnostic development.
Coronavirus has become major global threat as it is rapidly spreading across the world originating from China. There is no treatment exists which effectively control the viral spread.
Considering the severity of the novel coronavirus there is an urgent need to identify potent analogue / inhibitors which targets and controls the viral replication. Coronavirus proteases are considered as attractive targets for the design of antiviral drugs.
The high-resolution crystal structure of main protease with its inhibitor has been very recently determined using x-ray crystallography. Therefore, we used this structure (PDB ID: 6LU7.pdb) to investigate atomic level interactions between main protease of corona virus and existing protease inhibitors using molecular modeling approach.
Currently an ongoing projects to build blood cell counters, a diagnostic tool. These measure the complete blood count (CBC) - RBC, WBC and platelets. The number of WBC increases with a bacterial infection and hence is used to differentiate a bacterial infection from a viral infection. Further, the device can also detect virus infected cells, if one can synthesise fluorescent antibodies that will bind to virus infected cells. The latter is of course a challenge for COVID-19 and is a project in itself. Note that such blood cell counters are available in India but all of them are imported. The IMPRINT, GoI project was to develop indigenous technology.