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  • Antiviral drug/molecule synthesis
  • Drug discovery / delivery / scale up
  • Diagnostic kits and approaches
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File Last modified on: Mon Dec 21, 2020 22:47:23
 

Technologies and Expertise available at IIT Bombay w.r.t COVID-19    Click here

Projects initiated by IIT Bombay for COVID-19 mitigation

Webinar on R&D at IIT Bombay for Covid-19 Mitigation (August 1, 2020)
  • Projects update (30 November 2020)
  • List of projects initiated
  • Product implementation/commercialization
  • A few R&D updates for COVID-19 mitigation

 

Click here to View full details of Technologies and Expertise available for Diagnostic kits and approaches

  • Diagnostic kits and approaches
Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
available for collaboration/
licensing
Ruchi Anand Diagnostics, sensors
  • Our lab can help with diagnostic as well as drug development 3D structure and drug pocket evolution as well as assay development.
  • Amit Agarwal Microdevice based diagnostics, improved point f care diagnostics
  • Four microdevices have been developed which can potentially be integrated with an appropriate point-of-care or diagnostic device. These are:
    1. Blood plasma separation microdevice
    2. 3d-Hydrodynamic Focusing
    3. Constant temperature microdevice
    4. Platelet-rich-plasma separation microdevice
    There is great value in selectively isolating and enriching platelets in plasma from whole blood with application in biomedical research and transfusion purposes.
  • Rahul Purwar ELiSa assays for antibody/antigen quantification; immune response
  • Handles many types of virus including HIV (of course mutated ones).
  • The main research interest in quantifying the immune response in population to understand the responders and non-responders.
  • This expertise can help industry, academia and government in multiple ways. For example:
    1. The team will be identifying the people, who have developed immunity after infection or vaccine candidates,
    2. The team can help diagnostic companies and can them developing ELiSa assays for antibody/ antigen quantification.
    Soumyo Mukherji Diagnostic for virus detection
  • Has worked on technology to differentiate virus and bacteria. Rapid confirmative categorization of infections in clinical settings as bacterial or viral is frequently challenging due to the vague presentations of diseases and symptomatic similarities.
  • Many earlier studies have shown the bactericidal effect of silver nanoparticles which, in the current study has been enhanced by synergistic action of polycationic chitosan stabilizers.
  • An impedimetric electro-active polymer (polyaniline) modified paper substrate has been developed for generic differentiation of bacteria and virus based on their interaction with chitosan stabilized silver nanoparticles.
  • These characteristic electrical impedance signatures of bacteria and virus, established here, have promising prospects in inexpensive and scalable bedside diagnostic development.
  • Ambaarish Kunwar Virus inhibitors, anti viral drugs
  • Coronavirus has become major global threat as it is rapidly spreading across the world originating from China. There is no treatment exists which effectively control the viral spread.
  • Considering the severity of the novel coronavirus there is an urgent need to identify potent analogue / inhibitors which targets and controls the viral replication. Coronavirus proteases are considered as attractive targets for the design of antiviral drugs.
  • The high-resolution crystal structure of main protease with its inhibitor has been very recently determined using x-ray crystallography. Therefore, we used this structure (PDB ID: 6LU7.pdb) to investigate atomic level interactions between main protease of corona virus and existing protease inhibitors using molecular modeling approach.
  • Sarika Mehra Virus assay/detection
  • Development of an alternate assay for detection of virus; Alternate way of PCR based assay for the detection of virus
  • M. Tirumkudulu Blood cell counters
  • Currently an ongoing projects to build blood cell counters, a diagnostic tool. These measure the complete blood count (CBC) - RBC, WBC and platelets. The number of WBC increases with a bacterial infection and hence is used to differentiate a bacterial infection from a viral infection. Further, the device can also detect virus infected cells, if one can synthesise fluorescent antibodies that will bind to virus infected cells. The latter is of course a challenge for COVID-19 and is a project in itself. Note that such blood cell counters are available in India but all of them are imported. The IMPRINT, GoI project was to develop indigenous technology.
  • Pradeep Kumar P.I Diagnostic tools for detection
  • Diagnostic tools for the detection of Virus:
  • Developing nucleic aptamers against viral antigens/proteins
  • Dipti Gupta Flexible and stretchable electronics; Organic electronic devices for biomedical applications
  • Developing diagnostic devices by using the known biochemistry
  • Wearable devices for monitoring health of COVID-19 patients
  • Rinti Banerjee Expertise in biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Development of nanocomposite coatings for antiviral effects
  • Rohit Srivastava
  • Development and testing of lateral flow based assay for detection of IgG/IgM antibodies in Covid19 infections
  • Rapid affordable antibody based tests for large scale screening of Cov2
  • Rohit Srivastava
  • Development and testing of lateral flow based assay for detection of COVID-19 antigen
  • Rapid antigen based test for Cov2 using LFIA
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