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Technologies and Expertise available at IIT Bombay w.r.t COVID-19    Click here

Projects initiated by IIT Bombay for COVID-19 mitigation

Webinar on R&D at IIT Bombay for Covid-19 Mitigation (August 1, 2020)

 
Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
available for collaboration/
licensing
S. Kotha Synthesis of antiviral compounds
  • Interested in preparing cage amines and test for covid-19 as potential antivirals, since adamentane amine is known as anti-viral.
    		•
    Suvarn S. Kulkarni Synthesis of vaccine candidates
  • Lab is specialized in chemical synthesis of complex glycans which are present on the surfaces of bacteria and viruses. These glycans can be conjugated with proteins for vaccine development.

  • For this approach, one needs to know the specific structures of the glycans. Small sugar based molecules can be synthesised, to be tested as virus entry inhibitors, if the details about the nature of host-virus interaction at molecular level are available
    • Santosh J. Gharpure Chemical Synthesis
  • His research expertise is related to synthesis and such expertise can be extended for addressing various needs.
    		•
    Ravindra Gudi Synthesis protocol for antiviral drugs
  • Look at standardizing and developing a chemical synthesis protocol for the anti-viral drug (Prof. Gudi ravigudi@iitb.ac.in, Prof. Mahajani sanjaym@che.iitb.ac.in, Prof. Wangikar wangikar@iitb.ac.in )
    		•
    Santosh Noronha Downstream process analysis
  • Analyze effective downstream processing for drug isolation, design formulations. (Prof. Noronha noronha@iitb.ac.in)
    		•
    I. N. N. Namboothiri Synthesis of anti virals
  • We can participate in the synthesis of anti-viral agents. Also we can provide structures of large number of compounds which can be subjected to virtual screening by computational methods to identify the lead compounds (I had a joint MSc project with Prof Prasenjit Bhowmik of BSBE) on similar approach.

  • We can also supply available compounds in good quantities if someone is interested in screening directly by experimental methods.
    		•
    Ruchi Anand Drug development
  • Our lab can help with diagnostic as well as drug development 3D structure and drug pocket evolution as well as assay development.
    		•
    Debabrata Maiti Design and large scale synthesis of anti viral agents
  • We are interested in synthesising anti-viral agents. New chemicals can be prepared by our methods and known anti-viral agents can be prepared in large scale. We can design and synthesize new anti-viral agents.

  • In collaboration with other research groups, we are interested in contributing generation and testing of various anti-viral agents which will be effective against COVID-19.

  • Our strength is to prepare new chemical entities in large numbers and quantities. We will be happy to write a proposal or can be part of a larger mission.
    • Rodney A. Fernandes Synthesis of anti bacterials and anti virals
  • We can join with expertise in organic synthesis of compounds that can be tested. We have some compounds that worked well as anti-bacterials but not tested for antiviral. These can be tried for antiviral activity.
    		•
    Rahul Purwar Virus assays?
  • Handles many types of virus including HIV (of course mutated ones).

  • The main research interest in quantifying the immune response in population to understand the responders and non-responders.

  • This expertise can help industry, academia and government in multiple ways. For example:

    1. The team will be identifying the people, who have developed immunity after infection or vaccine candidates,
    2. The team can help diagnostic companies and can them developing ELiSa assays for antibody/ antigen quantification.
    		•
  • PI : Kiran Kondabagil
  • CoPI: Rinti Banerjee
  • CoPI : Shamik Sen
  • CoPI : Ashutosh Kumar
    		•  Various aspects of Virology; therapy development
  • Have experience in all aspects of virology, from culture to cultivation to understanding their biology/evolution, detection of viruses, and therapy development.
  • In-situ Gel for Rapid Capture and Inactivation of 2019-nCoV
    		•
    Rinti Banerjee Biomaterials, encapsulation technology, drug delivery and nanomedicine PICOVRID technology: Antiviral prophylactics and therapy

    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    J. Bellare Nanoparticle based drug delivery, Structure analysis
  • Nanoparticle based drug delivery and formulation (Prof. Bellare; jb@iitb.ac.in)
  • Cryo-Electron microscopy to determine the structure of SARS-CoV-2 spike protein and its cellular receptor during infection. This could be helpful for design of new molecules or in decision on repurposing existing molecules.(Prof. Bellare; jb@iitb.ac.in)
    		•
    K. V. Venkatesh Data driven models
  • Perform drug release studies and determine optimal drug dosage (Prof Venkatesh (venks@iitb.ac.in, Prof. Bellare jb@iitb.ac.in)
  • Analyze and monitor clinical study through systems biology (Prof. Venkatesh; venks@iitb.ac.in)
    		•
    Ravindra Gudi Scale up models
  • Assist in scale up through models and also data driven models (Prof. Venkatesh venks@iitb.ac.in, Prof. Gudi ravigudi@iitb.ac.in)
    		•
    Pradeep Kumar P.I Targeted therapy development
  • Targeting non-canonical structures of COVID-19 genomic RNA by small-molecule ligands;
  • Developing functional nucleic acids like aptamers/siRNAs /antisense oligos against COVID-19 proteins
    		•
    Sanjeeva Srivastava

    Collaborators: Dr.Om Shrivastav, Jaslok Hospital Dr. Jayanthi S. Shastri, (T N Medical College & Nair Hospital) Specialist at Kasturba, Nair & Jaslok Hospitals.     		Proteomic analysis
  • Proteomic analysis
    		•
  • Identification of global metabolite biomarkers in COVID-19 infected patients for targeted therapy
  • Plasma Proteomic Analysis of COVID-19 patients to identify the potential biomarkers and therapeutic targets
    		•
    Rinti Banerjee Expertise in biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Development of drug delivery platforms for sustained delivery of antiviral drugs for oral, buccal, nasal, aerosol routes
  • Development of nanoparticle adjuvants for vaccine delivery
  • Development of high absorption nutraceutical formulations including solubilisation of water insoluble bioactives
  • Development of dissolvable microneedle platforms for vaccine delivery
  • Development of oral and dermal formulations for delivery of nutrients for enhanced immunity
    		•
  • Aerosols for Acute Respiratory Distress Syndrome complications of COVID 19
  • Nutraceutical with antiviral and anti-inflammatory properties
    		•

    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    Ruchi Anand Diagnostics, sensors
  • Our lab can help with diagnostic as well as drug development 3D structure and drug pocket evolution as well as assay development.
    		•
    Amit Agarwal Microdevice based diagnostics, improved point f care diagnostics
  • Four microdevices have been developed which can potentially be integrated with an appropriate point-of-care or diagnostic device. These are:
    1. Blood plasma separation microdevice
    2. 3d-Hydrodynamic Focusing
    3. Constant temperature microdevice
    4. Platelet-rich-plasma separation microdevice
    There is great value in selectively isolating and enriching platelets in plasma from whole blood with application in biomedical research and transfusion purposes.
    • Rahul Purwar ELiSa assays for antibody/antigen quantification; immune response
  • Handles many types of virus including HIV (of course mutated ones).
  • The main research interest in quantifying the immune response in population to understand the responders and non-responders.
  • This expertise can help industry, academia and government in multiple ways. For example:
    1. The team will be identifying the people, who have developed immunity after infection or vaccine candidates,
    2. The team can help diagnostic companies and can them developing ELiSa assays for antibody/ antigen quantification.
    Soumyo Mukherji Diagnostic for virus detection
  • Has worked on technology to differentiate virus and bacteria. Rapid confirmative categorization of infections in clinical settings as bacterial or viral is frequently challenging due to the vague presentations of diseases and symptomatic similarities.
  • Many earlier studies have shown the bactericidal effect of silver nanoparticles which, in the current study has been enhanced by synergistic action of polycationic chitosan stabilizers.
  • An impedimetric electro-active polymer (polyaniline) modified paper substrate has been developed for generic differentiation of bacteria and virus based on their interaction with chitosan stabilized silver nanoparticles.
  • These characteristic electrical impedance signatures of bacteria and virus, established here, have promising prospects in inexpensive and scalable bedside diagnostic development.
    		•
    Ambaarish Kunwar Virus inhibitors, anti viral drugs
  • Coronavirus has become major global threat as it is rapidly spreading across the world originating from China. There is no treatment exists which effectively control the viral spread.
  • Considering the severity of the novel coronavirus there is an urgent need to identify potent analogue / inhibitors which targets and controls the viral replication. Coronavirus proteases are considered as attractive targets for the design of antiviral drugs.
  • The high-resolution crystal structure of main protease with its inhibitor has been very recently determined using x-ray crystallography. Therefore, we used this structure (PDB ID: 6LU7.pdb) to investigate atomic level interactions between main protease of corona virus and existing protease inhibitors using molecular modeling approach.
    		•
    Sarika Mehra Virus assay/detection
  • Development of an alternate assay for detection of virus; Alternate way of PCR based assay for the detection of virus
    		•
    M. Tirumkudulu Blood cell counters
  • Currently an ongoing projects to build blood cell counters, a diagnostic tool. These measure the complete blood count (CBC) - RBC, WBC and platelets. The number of WBC increases with a bacterial infection and hence is used to differentiate a bacterial infection from a viral infection. Further, the device can also detect virus infected cells, if one can synthesise fluorescent antibodies that will bind to virus infected cells. The latter is of course a challenge for COVID-19 and is a project in itself. Note that such blood cell counters are available in India but all of them are imported. The IMPRINT, GoI project was to develop indigenous technology.
    		•
    Pradeep Kumar P.I Diagnostic tools for detection
  • Diagnostic tools for the detection of Virus:
  • Developing nucleic aptamers against viral antigens/proteins
    		•
    Dipti Gupta Flexible and stretchable electronics; Organic electronic devices for biomedical applications
  • Developing diagnostic devices by using the known biochemistry
  • Wearable devices for monitoring health of COVID-19 patients
    		•
    Rinti Banerjee Expertise in biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Development of nanocomposite coatings for antiviral effects
    		•
    Rohit Srivastava
  • Development and testing of lateral flow based assay for detection of IgG/IgM antibodies in Covid19 infections
    		•
  • Rapid affordable antibody based tests for large scale screening of Cov2
    		•
    Rohit Srivastava
  • Development and testing of lateral flow based assay for detection of COVID-19 antigen
    		•
  • Rapid antigen based test for Cov2 using LFIA
    • '

    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    R.Sunoj ML in drug discovery and process
  • Our recent efforts in the use of machine learning is applicable to drug discovery and process (such as catalytic reactions) related to efficient generation of such potentially active compounds.
  • We would like to use a combination of density functional theory computations to accelerate the process of identifying lead compounds.
    		•
    Maryam Baghini Translational research and technology development
  • Non-invasive and minimally-invasive devices for health monitoring, diagnosis an biotelemetry in portable, wearable and implantable applications with support features based on IoT; Team has demonstrated a full working prototype using in-house designed ASICs (application specific integrated circuits) with artifact-tolerant signal conditioning and record noise efficiency factor for multi-parameter multi-channel for both monitoring and pre-diagnosis purposes with MedRadio biotelemetry; working on the development of several size-reduced, indigenous and improved measurement devices used in the clinics by the doctors; Also works on machine learning based techniques for pre-diagnosis applications
    		•

    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    Sandeep Kumar
    Sanjay Mahajani
  • Incinerator for waste disposal
    		•
  • Development of Incineration device for safe disposal of Masks/Gloves in Hospitals and Quarantine Centres
    		•
  • PI : Ambarish Kunwar
  • CoPI : Kiran Kondabagil

    • Product design:
  • P. Kumaresan
  • Purba Joshi
    		•
  • Portable UVC Germicidal Unit
    		•
  • Technology for Portable / Wheeled UVC Germicidal Unit / station for Disinfection
    Product implementation/commercialization
    • Soumyo Mukherji
    Suparna Mukherji    		 Decontamination technologies
  • Agents for decontamination and antiviral action
    		•
  • Surface spray for decontamination and antiviral action
    		•
    Soumyo Mukherji Biosensors and Bioinstrumentation
  • Has worked on technology to differentiate virus and bacteria. Rapid confirmative categorization of infections in clinical settings as bacterial or viral is frequently challenging due to the vague presentations of diseases and symptomatic similarities.
  • Many earlier studies have shown the bactericidal effect of silver nanoparticles which, in the current study has been enhanced by synergistic action of polycationic chitosan stabilizers.
  • An impedimetric electro-active polymer (polyaniline) modified paper substrate has been developed for generic differentiation of bacteria and virus based on their interaction with chitosan stabilized silver nanoparticles.
  • These characteristic electrical impedance signatures of bacteria and virus, established here, have promising prospects in inexpensive and scalable bedside diagnostic development.
    		•
  • Sanitisation solution for hands for Institute personnel
    		•
    Rinti Banerjee Biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Development of nanocomposite coatings for antiviral effects
    		•
    Rinti Banerjee Biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Phytoformulations developed for walkthrough sanitizers with Thermax
  • To be evaluated as aerosol sprays in tunnels
  • Hand rub version also developed
    		•  Walk-through sanitizers

    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    J. Bellare Agents for decontamination and antiviral action
  • Low-cost ventilator for emergency use [already in progress with collaboration with HN Hospital]
    • PI's
  • Soham Mujumdar
  • Ramesh Singh
  • Ankit Jain
  • Ashutosh Gupta
    		•
  • Low cost ventilator
    		•
  • Development of Low-cost ventilator

    • Related Links
    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
  • Bhaskar Raman
  • Kameshwari Chebrolu
    		•
  • Use of "SAFE" app for Quarantine Adherence, http://safe.cse.iitb.ac.in/
    		•
  • Ganesh Ramakrishnan
  • Manjesh K Hanawal, IE OR
    		•  Communication Networks Machine Learning

    Network Economics
  • Real time contact tracing through Corontine application
    		•
  • CORONTINE: Tracking and Tracing of Asymptotic Carriers During Pandemic
    https://corontine.in/

    • Related Links
    Bhaskar Raman Computing and communication system design
  • Privacy Preserving Contact Tracing
    		•
    Ganesh Ramakrishnan
  • Real-time application solution deployed at different quarantine locations at IITB
    		•
  • Contactless (video) surveillance at COVID-19 quarantine facilities

    • Related Links
    Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    Kameshwari Chebrolu
  • World Wide Help: IT solution for user-friendly, cost effective and customized information access on any topic and in any domain with humans-in-the-loop
    URL: Click here

    Use case
    Related Links
    • Bhaskar Raman Computing and communication system design
  • Implemented at IITB and local grocery stores
    		•
  • E-token and online ordering system

    • Related Links
    P. Sunthar
  • Web application for various medical inventory across districts, states and at the national level
    		•
  • Short-term projection of COVID-19 medical resources and inventory https://covid19medinventory.in/
    		•
    Ganesh Ramakrishnan Communication Networks Machine Learning
  • Implemented at IITB and local grocery stores
    		•
  • Lokacart: Client & Admin apps, Admin web portal for farmer groups and grocery stores

    • Related Links
  • Ganesh Ramakrishnan
  • Preethi Jyothi
    		•  Communication Networks Machine Learning

    Automatic Speech Recognition, Machine learning
  • Deployed at Ekal Vidyalaya to train their village level teachers Related Link
  • Using LV, Ekal has achieved knowledge retention, delivery and planning, effective training and tracking
  • Platform is actively being used by Ekal even during Covid-19 lockdown
    		•
  • Lokavidya: Knowledge sharing platform for educational institutions

    • Related Links

    Student Led Efforts

    Student Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
    Student COVID PPE Tracker:
  • Platform to connect people willing to donate and people who require PPE
    Related Links

    • Faculty(Prof.) Expertise Participation Details Projects Initiated Technologies developed/
    available for collaboration/
    licensing
  • P. Kumaresan
  • Purba Joshi
  • B.K. Chakravarthy
    		•
  • Face masks for Institute personnel
    Related Links
    • Rinti Banerjee Expertise in biomaterials, encapsulation technology, drug delivery and nanomedicine
  • Wash resistant antibacterial coating for medical textiles
  • Wash resistant antiviral coating for medical textiles
  • Biodegradable antiviral and antibacterial barrier films for face shields and personal protective equipment
    		•
    Rohit Srivastava
  • Antiviral gel spray for coating cloth masks to make them safe against COVID19
    		•
    Faculty(Prof.) Product Details Images
  • Ambarish Kunwar
  • Kiran Kondabagil
  • P. Kumaresan
  • Purba Joshi
    		•  Portable UV santizer unit deployed at IITB Hospital
    •